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KMID : 0191120150300010034
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Journal of Korean Medical Science
2015 Volume.30 No. 1 p.34 ~ p.43
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Cardioprotective Effect of Fimasartan, a New Angiotensin Receptor Blocker, in a Porcine Model of Acute Myocardial Infarction
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Sim Doo-Sun
Song Ho-Chun
Kim Ja-Hae
Chong A-Ri
Bom Hee-Seung
Jeong In-Seok
Oh Sang-Gi
Kim Jong-Min
Park Dae-Sung
Kim Jung-Ha
Lim Kyung-Seob
Kim Min-Suk
Ryu Shi-Hyun
Kim Hyun-Kuk
Kim Sung-Soo
Jang Su-Young
Cho Jae-Yeong
Jeong Hae-Chang
Lee Ki-Hong
Park Keun-Ho
Yoon Nam-Sik
Yoon Hyun-Ju
Kim Kye-Hun
Hong Young-Joon
Park Hyung-Wook
Kim Ju-Han
Ahn Young-Keun
Cho Jeong-Gwan
Park Jong-Chun
Kang Jung-Chaee
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Abstract
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Cardioprotective effect of fimasartan, a new angiotensin receptor blocker (ARB), was evaluated in a porcine model of acute myocardial infarction (MI). Fifty swine were randomized to group 1 (sham, n=10), group 2 (no angiotensin-converting enzyme inhibitor [ACEI] or ARB, n=10), group 3 (perindopril 2 mg daily, n=10), group 4 (valsartan 40 mg daily, n=10), or group 5 (fimasartan 30 mg daily, n=10). Acute MI was induced by occlusion of the left anterior descending artery for 50 min. Echocardiography, single photon emission computed tomography (SPECT), and F-18 fluorodeoxyglucose cardiac positron emission tomography (PET) were performed at baseline, 1 week, and 4 weeks. Iodine-123 meta-iodobenzylguanidine (MIBG) scan was done at 6 weeks for visualization of cardiac sympathetic activity. Left ventricular function and volumes at 4 weeks were similar between the 5 groups. No difference was observed in groups 2 to 5 in SPECT perfusion defect, matched and mismatched segments between SPECT and PET at 1 week and 4 weeks. MIBG scan showed similar uptake between the 5 groups. Pathologic analysis showed similar infarct size in groups 2 to 5. Infarct size reduction was not observed with use of fimasartan as well as other ACEI and ARB in a porcine model of acute MI.
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KEYWORD
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Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, Myocardial Infarction
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